Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 289, Issue 47, Pages -Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M114.582460
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Funding
- National Institutes of Health [NR010797]
- Dr. Miriam and Sheldon G. Adelson Foundation
- Center for Research Excellence in Spinal Cord Injury [DOHC019772]
- Burke Medical Research Institute Foundation
- Spanish Ministry of Science and Innovation [SAF2011-22855]
- Generalitat Valenciana [Prometeo/2012/005]
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To regenerate damaged axons, neurons must express a cassette of regeneration-associated genes (RAGs) that increases intrinsic growth capacity and confers resistance to extrinsic inhibitory cues. Here we show that dibutyrl-cAMP or forskolin combined with constitutive-active CREB are superior to either agent alone in driving neurite growth on permissive and inhibitory substrates. Of the RAGs examined, only arginase 1 (Arg1) expression correlated with the increased neurite growth induced by the cAMP/CREB combination, both of which were AP1-dependent. This suggests that cAMP-induced AP1 activity is necessary and interacts with CREB to drive expression of RAGs relevant for regeneration and demonstrates that combining a small molecule (cAMP) with an activated transcription factor (CREB) stimulates the gene expression necessary to enhance axonal regeneration.
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