Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 289, Issue 50, Pages 34440-34448Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R114.595439
Keywords
Epigenetics; Glycobiology; O-GlcNAcylation; Polycomb; RNA Polymerase II; Signaling; Histones; O-GlcNAc; Transcription
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Funding
- National Institutes of Health from NCI
- NIDDK
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O-GlcNAcylation is an abundant nutrient-driven modification linked to cellular signaling and regulation of gene expression. Utilizing precursors derived from metabolic flux, O-GlcNAc functions as a homeostatic regulator. The enzymes of O-GlcNAc cycling, OGT and O-GlcNAcase, act in mitochondria, the cytoplasm, and the nucleus in association with epigenetic writers and erasers of the histone code. Both O-GlcNAc and O-phosphate modify repeats within the RNA polymerase II C-terminal domain (CTD). By communicating with the histone and CTD codes, O-GlcNAc cycling provides a link between cellular metabolic status and the epigenetic machinery. Thus, O-GlcNAcylation is poised to influence trans-generational epigenetic inheritance.
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