Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 290, Issue 4, Pages 2508-2520Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M114.603761
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Funding
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA01010201]
- National Key Basic Research and Development Program of China [2014CB964804, 2015CB964500]
- National Natural Science Foundation of China [91219303, 31430058]
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Background: H3K9Ac is an epigenetic mark representing transcriptionally active chromatin. Results: Inhibition of HDAC activity promotes pluripotency maintenance at the initiation of hESC differentiation and inhibits neural differentiation during neural commitment stage. Conclusion: H3K9Ac plays dual roles in hESC pluripotency maintenance and neural differentiation through regulating different targets. Significance: This work provides insight into the epigenetic mechanisms underlying neural differentiation of hESCs associated with histone acetylation patterns.
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