Related references
Note: Only part of the references are listed.New concepts in pharmacological efficacy at 7TM receptors: IUPHAR Review 2
Terry Kenakin
BRITISH JOURNAL OF PHARMACOLOGY (2013)
OPINION Signalling bias in new drug discovery: detection, quantification and therapeutic impact
Terry Kenakin et al.
NATURE REVIEWS DRUG DISCOVERY (2013)
Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46
Laurent O. Mosnier et al.
BLOOD (2012)
β-Adrenergic Receptor Stimulation Transactivates Protease-Activated Receptor 1 via Matrix Metalloproteinase 13 in Cardiac Cells
Fabrice Jaffre et al.
CIRCULATION (2012)
Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects
R. A. Schuepbach et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2012)
Targeting proteinase-activated receptors: therapeutic potential and challenges
Rithwik Ramachandran et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis
Sarah L. Tressel et al.
EMBO MOLECULAR MEDICINE (2011)
Neutrophil Elastase Acts as a Biased Agonist for Proteinase-activated Receptor-2 (PAR2)
Rithwik Ramachandran et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Functional Selectivity and Biased Receptor Signaling
Terry Kenakin
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)
Structure, function and pathophysiology of protease activated receptors
Mark N. Adams et al.
PHARMACOLOGY & THERAPEUTICS (2011)
Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through β-arrestin and dishevelled-2 scaffolds
Unice J. K. Soh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Differential association modes of the thrombin receptor PAR1 with Gαi1, Gα12, and β-arrestin 1
Mohammed Akli Ayoub et al.
FASEB JOURNAL (2010)
Teaching old receptors new tricks: biasing seven-transmembrane receptors
Sudarshan Rajagopal et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Blockade of PAR1 Signaling with Cell-Penetrating Pepducins Inhibits Akt Survival Pathways in Breast Cancer Cells and Suppresses Tumor Survival and Metastasis
Eric Yang et al.
CANCER RESEARCH (2009)
Platelet Matrix Metalloprotease-1 Mediates Thrombogenesis by Activating PAR1 at a Cryptic Ligand Site
Vishal Trivedi et al.
CELL (2009)
Parstatin, the Cleaved Peptide on Proteinase-Activated Receptor 1 Activation, Is a Potent Inhibitor of Angiogenesis
Panagiota Zania et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
Agonist-Biased Signaling via Proteinase Activated Receptor-2: Differential Activation of Calcium and Mitogen-Activated Protein Kinase Pathways
Rithwik Ramachandran et al.
MOLECULAR PHARMACOLOGY (2009)
A matrix metalloproteinase-1/protease activated receptor-1 signaling axis promotes melanoma invasion and metastasis
J. S. Blackburn et al.
ONCOGENE (2009)
Caveolae are required for protease-selective signaling by protease-activated receptor-1
Angela Russo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Matrix Metalloproteinase-1 and Thrombin Differentially Activate Gene Expression in Endothelial Cells via PAR-1 and Promote Angiogenesis
Jessica S. Blackburn et al.
AMERICAN JOURNAL OF PATHOLOGY (2008)
Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more
R. Ramachandran et al.
BRITISH JOURNAL OF PHARMACOLOGY (2008)
Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity
Samuel Chackalamannil et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Lipid raft localization regulates the cleavage specificity of protease activated receptor 1 in endothelial cells
J. -S. Bae et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2008)
Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin
Reto A. Schuepbach et al.
BLOOD (2008)
The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a banier-protective response in endothelial cells
Jong-Sup Bae et al.
BLOOD (2007)
Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia
Wolfgang Knecht et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Proteolysis of the endothelial cell protein C receptor by neutrophil proteinase 3
A. Villegas-Mendez et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2007)
Proteinase-activated receptors, targets for kallikrein signaling
Katerina Oikonomopoulou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Neutrophil serine proteases: specific regulators of inflammation
Christine T. N. Pham
NATURE REVIEWS IMMUNOLOGY (2006)
Mammalian cell-based optimization of the biarsenical-binding tetracysteine motif for improved fluorescence and affinity
BR Martin et al.
NATURE BIOTECHNOLOGY (2005)
Discovery of potent orally active thrombin receptor (protease activated receptor 1) antagonists as novel antithrombotic agents
S Chackalamannil et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1
JN McLaughlin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells
A Boire et al.
CELL (2005)
Proteinase-activated receptor 2: Differential activation of the receptor by tethered ligand and soluble peptide analogs
B Al-Ani et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Activation of endothelial cell protease activated receptor 1 by the protein C pathway
M Riewald et al.
SCIENCE (2002)
Cyclic AMP-elevating agents induce the expression of MAP kinase phosphatase-1 in PC12 cells
C Burgun et al.
FEBS LETTERS (2000)
Share Paper
