Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 287, Issue 14, Pages 11070-11081Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M111.302547
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Funding
- National Institutes of Health [R01 CA155413]
- Drexel University College of Medicine CURE
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Background: Cancer cells display altered metabolism and expression of the nutrient sensor O-linked beta-N-acetylglucosamine transferase (OGT). Results: Through regulation of FoxM1, OGT contributes to increased invasion, angiogenesis, and metastasis of prostate cancer cells. Conclusion: OGT plays a critical role in prostate cancer. Significance: OGT may provide a novel therapeutic target for treating prostate cancer.
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