Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

Background: Exosome is a membrane vesicle released from several types of cells, including neurons. Results: Neuronal exosomes accelerate A beta fibril formation, and the exosome-associated A beta is taken into microglia to degrade it. Conclusion: Exosomes promote A beta clearance. Significance: These findings provide a new function of exosome in the brain and also suggest its involvement in the development of Alzheimer disease.