Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 287, Issue 51, Pages 42444-42452Publisher
ELSEVIER
DOI: 10.1074/jbc.R112.402768
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Funding
- National Institutes of Health [AG032375, DK088190, GM093072, T32 DK007260]
- Beatriu de Pinos postdoctoral fellowship
- Paul F. Glenn Foundation for Medical Research
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Originally rising to notoriety for their role in the regulation of aging, sirtuins are a family of NAD(+)-dependent enzymes that have been connected to a steadily growing set of biological processes. In addition to regulating aging, sirtuins play key roles in the maintenance of organismal metabolic homeostasis. These enzymes also have primarily protective functions in the development of many age-related diseases, including cancer, neurodegeneration, and cardiovascular disease. In this minireview, we provide an update on the known roles for each of the seven mammalian sirtuins in these areas.
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