Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 287, Issue 39, Pages 32394-32405Publisher
ELSEVIER
DOI: 10.1074/jbc.M112.393900
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Funding
- 973 National Key Fundamental Research Program of China [2011CB911004, 2011CB910801]
- National Natural Science Foundation of China [81071633]
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Migfilin is critical for cell shape and motile regulation. However, its pathological role in glioma is unknown. Using an immunohistochemical staining assay, we demonstrate that there is a significant correlation between expression of Migfilin and pathological tumor grade in 217 clinical glioma samples. High Migfilin expression is associated with poor prognosis for patients with glioma. Investigation of the molecular mechanism shows that Migfilin promotes migration and invasion in glioma cells. Moreover, Migfilin positively modulates the expression and activity of epidermal growth factor receptor, and Migfilin-mediated migration and invasion depend on epidermal growth factor receptor-induced PLC-gamma and STAT3-signaling pathways. Our results may provide significant clinical application, including use of Migfilin as a molecular marker in glioma for early diagnosis and as an indicator of prognosis.
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