Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 287, Issue 19, Pages 15570-15579Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M112.357848
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Funding
- Naito Foundation
- National Institute of Biomedical Innovation
- Genome Pharmaceuticals Institute
- Grants-in-Aid for Scientific Research [11J11070, 23249009] Funding Source: KAKEN
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Staphylococcus aureus spreads on the surface of soft agar, a phenomenon we termed colony spreading. Here, we found that S. aureus culture supernatant inhibited colony spreading. We purified delta-hemolysin (Hld, delta-toxin), a major protein secreted from S. aureus, as a compound that inhibits colony spreading. The culture supernatants of hld-disrupted mutants had 30-fold lower colony-spreading inhibitory activity than those of the parent strain. Furthermore, hld-disrupted mutants had higher colony-spreading ability than the parent strain. These results suggest that S. aureus negatively regulates colony spreading by secreting delta-hemolysin.
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