Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 287, Issue 21, Pages 17656-17661Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.C112.367110
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Funding
- Agence Nationale de la Recherche ANTARES
- MINOS
- Deutsche Forschungsgemeinschaft-KForG Innate Immunity TP2
- Bundesministerium fur Bildung, Wissenschaft, Forschung und Technologie (NGFNplus)
- European Union EPICURE
- National Institutes of Health National Research Service Award postdoctoral fellowship [NS056664]
- National Institutes of Health [T32 NS45540, T32 NS43124, NS049427, NS039943, NS35439]
- Conventions Industrielles de Formation par la REcherche fellowship
- Epilepsy Foundation
- Institut de la Sante et de la Recherche Medicale
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The dorsal and ventral regions of the hippocampus perform different functions. Whether the integrative properties of hippocampal cells reflect this heterogeneity is unknown. We focused on dendrites where most synaptic input integration takes place. We report enhanced backpropagation and theta resonance and decreased summation of synaptic inputs in ventral versus dorsal CA1 pyramidal cell distal dendrites. Transcriptional Kv4.2 down-regulation and post-transcriptional hyperpolarization-activated cyclic AMP-gated channel (HCN1/2) up-regulation may underlie these differences, respectively. Our results reveal differential dendritic integrative properties along the dorso-ventral axis, reflecting diverse computational needs.
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