4.6 Article

Increasing Serum Half-life and Extending Cholesterol Lowering in Vivo by Engineering Antibody with pH-sensitive Binding to PCSK9

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo

Yan G. Ni et al.

JOURNAL OF LIPID RESEARCH (2011)

Article Biochemistry & Molecular Biology

A Combinatorial Histidine Scanning Library Approach to Engineer Highly pH-Dependent Protein Switches

Megan L. Murtaugh et al.

PROTEIN SCIENCE (2011)

Review Pharmacology & Pharmacy

Biodistribution Mechanisms of Therapeutic Monoclonal Antibodies in Health and Disease

Mohammad Tabrizi et al.

AAPS JOURNAL (2010)

Review Pharmacology & Pharmacy

Population Pharmacokinetics of Therapeutic Monoclonal Antibodies

Nathanael L. Dirks et al.

CLINICAL PHARMACOKINETICS (2010)

Review Chemistry, Medicinal

Strategies for proprotein convertase subtilisin kexin 9 modulation: a perspective on recent patents

Marianne Abifadel et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2010)

Article Biotechnology & Applied Microbiology

Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization

Tomoyuki Igawa et al.

NATURE BIOTECHNOLOGY (2010)

Article Biotechnology & Applied Microbiology

Enhanced antibody half-life improves in vivo activity

Jonathan Zalevsky et al.

NATURE BIOTECHNOLOGY (2010)

Article Biotechnology & Applied Microbiology

Development trends for human monoclonal antibody therapeutics

Aaron L. Nelson et al.

NATURE REVIEWS DRUG DISCOVERY (2010)

Review Cardiac & Cardiovascular Systems

Molecular basis of PCSK9 function

Gilles Lambert et al.

ATHEROSCLEROSIS (2009)

Article Biochemistry & Molecular Biology

Structural and Biochemical Characterization of the Wild Type PCSK9-EGF(AB) Complex and Natural Familial Hypercholesterolemia Mutants

Matthew J. Bottomley et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

PCSK9: a convertase that coordinates LDL catabolism

Jay D. Horton et al.

JOURNAL OF LIPID RESEARCH (2009)

Article Multidisciplinary Sciences

A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates

Joyce C. Y. Chan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Pharmacology & Pharmacy

Monoclonal Antibody Pharmacokinetics and Pharmacodynamics

W. Wang et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2008)

Article Multidisciplinary Sciences

Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor

Da-Wei Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Cardiac & Cardiovascular Systems

The C679X mutation in PCSK9 is present and lowers blood cholesterol in a Southern African population

Amanda J. Hooper et al.

ATHEROSCLEROSIS (2007)

Article Biochemistry & Molecular Biology

The crystal structure of PCSK9: A regulator of plasma LDL-cholesterol

Derek E. Piper et al.

STRUCTURE (2007)

Article Pharmacology & Pharmacy

A mechanism-based binding model for the population pharmacokinetics and pharmacodynamics of omalizumab

Naoto Hayashi et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2007)

Article Medicine, General & Internal

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

JC Cohen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Article Multidisciplinary Sciences

Engineered antibody Fc variants with enhanced effector function

GA Lazar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Genetics & Heredity

A spectrum of PCSK9 Alleles contributes to plasma levels of low-density lipoprotein cholesterol

IK Kotowski et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2006)

Review Pharmacology & Pharmacy

Elimination mechanisms of therapeutic monoclonal antibodies

MA Tabrizi et al.

DRUG DISCOVERY TODAY (2006)

Article Genetics & Heredity

Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote

Zhenze Zhao et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2006)

Article Genetics & Heredity

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

M Abifadel et al.

NATURE GENETICS (2003)

Article Biotechnology & Applied Microbiology

Rational cytokine design for increased lifetime and enhanced potency using pH-activated histidine switching

CA Sarkar et al.

NATURE BIOTECHNOLOGY (2002)