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Liquid Chromatography-Mass Spectrometry-based Quantitative Proteomics

Journal

JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 286, Issue 29, Pages 25443-25449

Publisher

AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R110.199703

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Funding

  1. National Institutes of Health from the National Center for Research Resources for Integrative Biology [RR018522]
  2. United States Department of Energy
  3. Battelle for the Department of Energy [DE-AC05-76RLO 1830]

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LC-MS-based quantitative proteomics has become increasingly applied to a wide range of biological applications due to growing capabilities for broad proteome coverage and good accuracy and precision in quantification. Herein, we review the current LC-MS-based quantification methods with respect to their advantages and limitations and highlight their potential applications.

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