Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 286, Issue 50, Pages 43026-43038Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M111.253419
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
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Background: Rational design methods can be used to create chimeric enzymes with novel catalytic combinations. Results: Bifunctional enzymes combining xylanase and laccase activities showed enhanced catalytic activity and stability. Conclusion: Formation of an inter-domain interface alters enzyme conformation that enhances catalytic performance of the chimera. Significance: Deeper understanding of structural principles of protein fusion can improve the design of novel catalysts.
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