Related references
Note: Only part of the references are listed.Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors
Eric B. Lansdon et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
Synthesis, Activity, and Structural Analysis of Novel α-Hydroxytropolone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H
Suhman Chung et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Structure-Activity Analysis of Vinylogous Urea Inhibitors of Human Immunodeficiency Virus-Encoded Ribonuclease H
Suhman Chung et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Structural Basis for the Inhibition of RNase H Activity of HIV-1 Reverse Transcriptase by RNase H Active Site-Directed Inhibitors
Hua-Poo Su et al.
JOURNAL OF VIROLOGY (2010)
Crystallographic Study of a Novel Subnanomolar Inhibitor Provides Insight on the Binding Interactions of Alkenyldiarylmethanes with Human Immunodeficiency Virus-1 Reverse Transcriptase
Matthew D. Cullen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
RNase H Active Site Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase: Design, Biochemical Activity, and Structural Information
Thorsten A. Kirschberg et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
HIV-1 Reverse Transcriptase Can Simultaneously Engage Its DNA/RNA Substrate at Both DNA Polymerase and RNase H Active Sites: Implications for RNase H Inhibition
Greg L. Beilhartz et al.
JOURNAL OF MOLECULAR BIOLOGY (2009)
Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active Site
Daniel M. Himmel et al.
STRUCTURE (2009)
Vinylogous Ureas as a Novel Class of Inhibitors of Reverse Transcriptase-Associated Ribonuclease H Activity
Michaela Wendeler et al.
ACS CHEMICAL BIOLOGY (2008)
Dynamic binding orientations direct activity of HIV reverse transcriptase
Elio A. Abbondanzieri et al.
NATURE (2008)
High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations
Kalyan Das et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Retro-transduction by virus pseudotyped with glycoprotein ot vesicular stomatitis virus
Masahisa Ohishi et al.
VIROLOGY (2007)
Indolopyridones inhibit human immunodeficiency virus reverse transcriptase with a novel mechanism of action
Dirk Jochmans et al.
JOURNAL OF VIROLOGY (2006)
Structure-activity relationships of [2′,5′-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3′-spiro-5-(4-amino-1,2-oxathiole-2,2-dioxide) thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization
Nicolas Sluis-Cremer et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Dimerization of human immunodeficiency virus type 1 reverse transcriptase as an antiviral target
S. Srivastava et al.
CURRENT PHARMACEUTICAL DESIGN (2006)
Recent progress in the design of small molecule inhibitors of HIV RNase H
Klaus Klumpp et al.
CURRENT PHARMACEUTICAL DESIGN (2006)
HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site
Daniel M. Himmel et al.
ACS CHEMICAL BIOLOGY (2006)
Crystallography and the design of anti-AIDS drugs: Conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors
K Das et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2005)
In search of a novel anti-HIV drug:: Multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6dimethylphenyl] amino]-2-pyrimidinyl]amino]-benzonitrile (R278474, rilpivirine)
PAJ Janssen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Dissecting the effects of DNA polymerase and ribonuclease H inhibitor combinations on HIV-1 reverse-transcriptase activities
CA Shaw-Reid et al.
BIOCHEMISTRY (2005)
Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones
SR Budihas et al.
NUCLEIC ACIDS RESEARCH (2005)
Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants
K Das et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Mutagenesis of cysteine 280 of the reverse transcriptase of human immunodeficiency virus type-1: The effects on the ribonuclease H activity
Z Sevilya et al.
JOURNAL OF MOLECULAR BIOLOGY (2003)
Inhibition of HIV-1 ribonuclease H by a novel diketo acid, 4-[5-(benzoylamino)thien-2-yl]-2,4-dioxobutanoic acid
CA Shaw-Reid et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors
K Klumpp et al.
NUCLEIC ACIDS RESEARCH (2003)
Altering the RNase H primer grip of human immunodeficiency virus reverse transcriptase modifies cleavage specificity
JW Rausch et al.
BIOCHEMISTRY (2002)
Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA
SG Sarafianos et al.
EMBO JOURNAL (2001)
Probing contacts between the ribonuclease H domain of HIV-1 reverse transcriptase and nucleic acid by site-specific photocross-linking
JW Rausch et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Human immunodeficiency virus type 1 reverse transcriptase dimer destabilization by 1-{spiro[4-amino-2,2-dioxo-1,2-oxathiole-5,3′-[2′,5′-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]]}-3-ethylthymine
N Sluis-Cremer et al.
BIOCHEMISTRY (2000)