Interplay between Vascular Endothelial Growth Factor (VEGF) and Nuclear Factor Erythroid 2-related Factor-2 (Nrf2) IMPLICATIONS FOR PREECLAMPSIA

Background: Several studies have suggested that decreasing VEGF levels might result in placental oxidative stress in preeclampsia. Results: VEGF activates Nrf2 in an ERK1/2-dependent manner, protecting against oxidative stress, and, in turn, up-regulates VEGF expression. Conclusion: Reduced VEGF bioavailability may lead to aggregation of oxidative stress and result in preeclampsia. Significance: Nrf2 activation might be considered as an adjunct therapeutic strategy to combat preeclampsia.