Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 286, Issue 50, Pages 42863-42872Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M111.286880
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Funding
- Deutsche Forschungsgemeinschaft [Pu 214/3-2, Pu 214/4-2, Pu 214/5-2, SFB617]
- START Program of the Faculty of Medicine
- RWTH Aachen University
- Department of Histology, Faculty of Medicine, Damascus University
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Background: Several studies have suggested that decreasing VEGF levels might result in placental oxidative stress in preeclampsia. Results: VEGF activates Nrf2 in an ERK1/2-dependent manner, protecting against oxidative stress, and, in turn, up-regulates VEGF expression. Conclusion: Reduced VEGF bioavailability may lead to aggregation of oxidative stress and result in preeclampsia. Significance: Nrf2 activation might be considered as an adjunct therapeutic strategy to combat preeclampsia.
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