Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 286, Issue 50, Pages 42855-42862Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M111.269456
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Funding
- Deutsche Krebshilfe
- Wilhelm-Sander-Stiftung
- Deutsche Forschungsgemeinschaft
- Graduate School of Chemistry, University of Munster
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Background: Pdcd4 is a tumor suppressor involved in translational regulation. Results: Pdcd4 interacts with p53 mRNA and inhibits its translation via the 5'-UTR. Under stress conditions, the expression of Pdcd4 decreases. Conclusion: Translation of p53 mRNA is suppressed by Pdcd4 under normal growth conditions. Significance: Pdcd4 is a new translational regulator of p53.
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