Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 286, Issue 50, Pages 42981-42991Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M111.310599
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Funding
- National Institute of Health [AR056296, AI088177]
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Background: Listeria monocytogenes is an intracellular pathogen that invades the host cytoplasm. Results: Cells deficient in TLR2 and NOD2 show defective autophagy of Listeria monocytogenes. Conclusion: Autophagy of Listeria is dependent on ERK pathway that is perturbed in TLR2- and NOD2-deficient cells. Significance: Our study establishes the role of innate immune receptors in autophagy of intracellular pathogens.
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