Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 286, Issue 26, Pages 22707-22710Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.C111.250407
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Funding
- National Multiple Sclerosis Society (NMSS)
- NIH through NIAID
- National Institutes of Health through NICHD
- NHLBI
- National Institute of Mental Health
- California Institute for Regenerative Medicine
- Prostate Cancer Foundation
- Fate Therapeutics
- Esther B. O'Keeffe Foundation
- Scripps Research Institute
- National Institutes of Health through NIAMS
- Leukemia and Lymphoma, Society
- M.D. Anderson Cancer Center
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Th17 cells have recently emerged as a major player in inflammatory and autoimmune diseases via the production of pro-inflammatory cytokines IL-17, IL-17F, and IL-22. The differentiation of Th17 cells and the associated cytokine production is directly controlled by ROR gamma t. Here we show that ursolic acid (UA), a small molecule present in herbal medicine, selectively and effectively inhibits the function of ROR gamma t, resulting in greatly decreased IL-17 expression in both developing and differentiated Th17 cells. In addition, treatment with UA ameliorated experimental autoimmune encephalomyelitis. The results thus suggest UA as a valuable drug candidate or leading compound for developing treatments of Th17-mediated inflammatory diseases and cancer.
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