Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 286, Issue 50, Pages 42808-42817Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M111.310169
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Funding
- National Institutes of Health [HL072925, CA117950, T32 GM008695, T31 HL094290, T32GM075762, NH1C06-RR17393]
- ONO Pharmaceutical Co., Ltd.
- American Heart Association [SDG0735350N]
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Background: Pro-TNF alpha is transformed into the active/soluble form through proteolysis by TNF alpha-converting enzyme (TACE). Results: Genetic ablation of ceramide kinase induces an increase in TACE activity and secreted TNF alpha. Conclusion: Ceramide 1-phosphate (C1P) negatively regulates the activity of TACE. Significance: The TACE/C1P interaction is a viable drug target for the treatment of heart disease and sepsis.
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