Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 286, Issue 38, Pages 32877-32882Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R110.215491
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Funding
- Spanish Ministry of Science and Innovation/Fondos Europeos de Desarrollo Regional (FEDER) [SAF2009-09848, Red HERACLES RD06/0009]
- Generalitat de Catalunya [2009SGR-1369]
- Fundacio la Marato de TV3 [080430, SAF2010-16725]
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Ion channels are specialized transmembrane proteins that permit the passive flow of ions following their electrochemical gradients. In the airways, ion channels participate in the production of epithelium-based hydroelectrolytic secretions and in the control of intracellular Ca2+ levels that will ultimately activate almost all lung cells, either resident or circulating. Thus, ion channels have been the center of many studies aiming to understand asthma pathophysiological mechanisms or to identify therapeutic targets for better control of the disease. In this mini-review, we focus on molecular, genetic, and animal model studies associating ion channels with asthma.
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