Related references
Note: Only part of the references are listed.Strategy for effective brain drug delivery
M. Intakhab Alam et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2010)
A Noncompetitive BACE1 Inhibitor TAK-070 Ameliorates Aβ Pathology and Behavioral Deficits in a Mouse Model of Alzheimer's Disease
Hiroaki Fukumoto et al.
JOURNAL OF NEUROSCIENCE (2010)
Getting into the Brain Approaches to Enhance Brain Drug Delivery
Mayur M. Patel et al.
CNS DRUGS (2009)
Synaptic NMDA Receptor Activation Stimulates α-Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-β Production
Sarah E. Hoey et al.
JOURNAL OF NEUROSCIENCE (2009)
Boom in the Development of Non-Peptidic beta-Secretase (BACE1) Inhibitors for the Treatment of Alzheimer Disease
Romano Silvestri
MEDICINAL RESEARCH REVIEWS (2009)
P-glycoprotein efflux and other factors limit brain amyloid β reduction by β-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice
Jere E. Meredith et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)
Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice
A. V. Savonenko et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Efficient inhibition of the Alzheimer's disease β-secretase by membrane targeting
Lawrence Rajendran et al.
SCIENCE (2008)
In vivo β-Secretase 1 inhibition leads to brain Aβ lowering and increased α-secretase processing of amyloid precursor protein without effect on neuregulin-1
Sethu Sankaranarayanan et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)
A reversible form of lysine acetylation in the ER and Golgi lumen controls the molecular stabilization of BACE1
Claudio Costantini et al.
BIOCHEMICAL JOURNAL (2007)
Amyloid-beta reduction by memapsin 2 (beta-secretase) immunization
Wan-Pin Chang et al.
FASEB JOURNAL (2007)
Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP transgenic mice
Lisa McConlogue et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases β-cleavage of amyloid precursor protein and amyloid-β production in vivo
Ishrut Hussain et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Positive reactions on Western blots do not necessarily indicate the epitopes on antigens are continuous
Yi-Hua Zhou et al.
IMMUNOLOGY AND CELL BIOLOGY (2007)
Bace1 modulates myelination in the central and peripheral nervous system
Xiangyou Hu et al.
NATURE NEUROSCIENCE (2006)
Control of peripheral nerve myelination by the β-secretase BACE1
Michael Willem et al.
SCIENCE (2006)
Alzheimer's disease β-amyloid peptides are released in association with exosomes
Lawrence Rajendran et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model
O Singer et al.
NATURE NEUROSCIENCE (2005)
Functional plasticity in the substrate binding site of β-secretase
AA Gorfe et al.
STRUCTURE (2005)
Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice
D Dominguez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid β protein -: art. no. 30
RM Carey et al.
BMC CELL BIOLOGY (2005)
Physiological regulation of the β-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation
WT Kimberly et al.
JOURNAL OF NEUROSCIENCE (2005)
Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (β-secretase)
RT Turner et al.
BIOCHEMISTRY (2005)
Flap position of free memapsin 2 (β-secretase), a model for flap opening in aspartic protease catalysis
L Hong et al.
BIOCHEMISTRY (2004)
Aβ is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis
MC Herzig et al.
NATURE NEUROSCIENCE (2004)
Structure-based design of potent and selective cell-permeable inhibitors of human β-secretase (BACE-1)
SJ Stachel et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Biochemical and kinetic characterization of BACE1:: investigation into the putative species-specificity for β- and β′-cleavage sites by human and murine BACE1
HC Yang et al.
JOURNAL OF NEUROCHEMISTRY (2004)
Fragment-based drug discovery
DA Erlanson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Assessment of the Bioactivity of Antibodies against beta-Amyloid Peptide in vitro and in vivo
M. Hasan Mohajeri et al.
NEURODEGENERATIVE DISEASES (2004)
Apo and inhibitor complex structures of BACE (β-secretase)
S Patel et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Characterization of the ectodomain shedding of the β-site amyloid precursor protein-cleaving enzyme 1 (BACE1)
I Hussain et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs
KMM Doan et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Crystal structure of memapsin 2 (β-secretase) in complex with an inhibitor OM00-3
L Hong et al.
BIOCHEMISTRY (2002)
Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
J Hardy et al.
SCIENCE (2002)
Specificity of memapsin 1 and its implications on the design of memapsin 2 (β-secretase) inhibitor selectivity
RT Turner et al.
BIOCHEMISTRY (2002)
Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins
WG Annaert et al.
NEURON (2001)
The transmembrane domain of the Alzheimer's β-secretase (BACE1) determines its late Golgi localization and access to β-amyloid precursor protein (APP) substrate
RQ Yan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Subsite specificity of memapsin 2 (β-secretase):: Implications for inhibitor design
RT Turner et al.
BIOCHEMISTRY (2001)
Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease
RB DeMattos et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
BACE knockout mice are healthy despite lacking the primary β-secretase activity in brain:: implications for Alzheimer's disease therapeutics
SL Roberds et al.
HUMAN MOLECULAR GENETICS (2001)
Characterization of the glycosylation profiles of Alzheimer's β-secretase protein Asp-2 expressed in a variety of cell lines
J Charlwood et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Phosphorylation regulates intracellular trafficking of β-secretase
J Walter et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Post-translational processing of β-secretase (β-amyloid-converting enzyme) and its ectodomain shedding -: The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-β production
S Benjannet et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation
Y Luo et al.
NATURE NEUROSCIENCE (2001)
BACE1 is the major β-secretase for generation of Aβ peptides by neurons
HB Cai et al.
NATURE NEUROSCIENCE (2001)
Processing of β-secretase by furin and other members of the proprotein convertase family
JWM Creemers et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Maturation and endosomal targeting of β-site amyloid precursor protein-cleaving enzyme -: The Alzheimer's disease β-secretase
JT Huse et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Structure of the protease domain of memapsin 2 (β-secretase) complexed with inhibitor
L Hong et al.
SCIENCE (2000)
Acetylation: a regulatory modification to rival phosphorylation?
T Kouzarides
EMBO JOURNAL (2000)
Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein
XL Lin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Share Paper
