Related references
Note: Only part of the references are listed.14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization
R. Jeremy Nichols et al.
BIOCHEMICAL JOURNAL (2010)
Leucine-rich repeat kinase 2 induces α-synuclein expression via the extracellular signal-regulated kinase pathway
Iria Carballo-Carbajal et al.
CELLULAR SIGNALLING (2010)
MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2
Cindy H. Hsu et al.
JOURNAL OF NEUROCHEMISTRY (2010)
LRRK2 and the Stress Response: Interaction with MKKs and JNK-Interacting Proteins
C. H. Hsu et al.
NEURODEGENERATIVE DISEASES (2010)
Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis
Venu M. Nemani et al.
NEURON (2010)
The Parkinson's Disease Associated LRRK2 Exhibits Weaker In Vitro Phosphorylation of 4E-BP Compared to Autophosphorylation
Azad Kumar et al.
PLOS ONE (2010)
ARHGEF7 (BETA-PIX) Acts as Guanine Nucleotide Exchange Factor for Leucine-Rich Repeat Kinase 2
Karina Haebig et al.
PLOS ONE (2010)
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
Cristofol Vives-Bauza et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions
Elisa Greggio et al.
ASN NEURO (2009)
Revelations and revolutions in the understanding of Parkinson's disease Preface
Ted M. Dawson et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2009)
PAK signalling in neuronal physiology
Patricia Kreis et al.
CELLULAR SIGNALLING (2009)
Investigation of leucine-rich repeat kinase 2
Vasanti S. Anand et al.
FEBS JOURNAL (2009)
Dependence of Leucine-rich Repeat Kinase 2 (LRRK2) Kinase Activity on Dimerization
Saurabh Sen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro
Christian Johannes Gloeckner et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment
Christian L. Klein et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Phosphorylation of Ezrin/Radixin/Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis
Loukia Parisiadou et al.
JOURNAL OF NEUROSCIENCE (2009)
The Parkinson Disease Protein Leucine-Rich Repeat Kinase 2 Transduces Death Signals via Fas-Associated Protein with Death Domain and Caspase-8 in a Cellular Model of Neurodegeneration
Cherry Cheng-Ying Ho et al.
JOURNAL OF NEUROSCIENCE (2009)
LRRK2 Modulates Vulnerability to Mitochondrial Dysfunction in Caenorhabditis elegans
Shamol Saha et al.
JOURNAL OF NEUROSCIENCE (2009)
CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity
Han Seok Ko et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
Yuzuru Imai et al.
EMBO JOURNAL (2008)
LRRK2 regulates synaptic vesicle endocytosis
Narae Shin et al.
EXPERIMENTAL CELL RESEARCH (2008)
Diverse roles of Rho family GTPases in neuronal development, survival, and death
Daniel A. Linseman et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2008)
Ezrin/radixin/moesin: Versatile controllers of signaling molecules and of the cortical cytoskeleton
Verena Niggli et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2008)
The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation
Elisa Greggio et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics
Stephen D. Smith et al.
JOURNAL OF CELL SCIENCE (2008)
Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells
Edward D. Plowey et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Genes associated with Parkinson syndrome
Saskia Biskup et al.
JOURNAL OF NEUROLOGY (2008)
Mitochondria in the aetiology and pathogenesis of Parkinson's disease
Anthony H. V. Schapira
LANCET NEUROLOGY (2008)
Mammalian Rho GTPases:: new insights into their functions from in vivo studies
Sarah J. Heasman et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway
Anthony K. F. Liou et al.
NEUROBIOLOGY OF DISEASE (2008)
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
Junpeng Deng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Direct binding of α-actinin enhances TRPP3 channel activity
Qiang Li et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin
Nicole Exner et al.
JOURNAL OF NEUROSCIENCE (2007)
LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity
Mahaboobi Jaleel et al.
BIOCHEMICAL JOURNAL (2007)
Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1
Elisa Greggio et al.
JOURNAL OF NEUROCHEMISTRY (2007)
The R1441C mutation of LRRK2 disrupts GTP hydrolysis
Patrick A. Lewis et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
MAPK-pathway activity, Lrrk2 G2019S, and Parkinson's disease
Linda R. White et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2007)
Understanding ERM proteins - the awesome power of genetics finally brought to bear
Sarah C. Hughes et al.
CURRENT OPINION IN CELL BIOLOGY (2007)
RIP1, a kinase on the crossroads of a cell's decision to live or die
N. Festjens et al.
CELL DEATH AND DIFFERENTIATION (2007)
The familial parkinsonism gene LRRK2 regulates neurite process morphology
David MacLeod et al.
NEURON (2006)
Localization of LRRK2 to membranous and vesicular structures in mammalian brain
Saskia Biskup et al.
ANNALS OF NEUROLOGY (2006)
Regulators of Rho GTPases in neuronal development
Mitsuko Watabe-Uchida et al.
JOURNAL OF NEUROSCIENCE (2006)
Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly
Fukun Guo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
LRRK2 in Parkinson's disease: protein domains and functional insights
Ignacio F. Mata et al.
TRENDS IN NEUROSCIENCES (2006)
LRRK2: a common pathway for parkinsonism, pathogenesis and prevention?
JP Taylor et al.
TRENDS IN MOLECULAR MEDICINE (2006)
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of α-synuclein, parkin, and DJ-1 in Caenorhabditis elegans
R Ved et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration
WW Smith et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Impaired degradation of mutant α-synuclein by chaperone-mediated autophagy
AM Cuervo et al.
SCIENCE (2004)
Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas
MC Subauste et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)