Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 287, Issue 5, Pages 3349-3356Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M111.295618
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Funding
- Japan Society for the Promotion of Science [20240038]
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) [23110510]
- Grants-in-Aid for Scientific Research [20240038] Funding Source: KAKEN
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To begin the process of forming neural circuits, new neurons first establish their polarity and extend their axon. Axon extension is guided and regulated by highly coordinated cytoskeletal dynamics. Here we demonstrate that in hippocampal neurons, the actin-binding protein caldesmon accumulates in distal axons, and its N-terminal interaction with myosin II enhances axon extension. In cortical neural progenitor cells, caldesmon knockdown suppresses axon extension and neuronal polarity. These results indicate that caldesmon is an important regulator of axon development.
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