Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 286, Issue 2, Pages 1269-1276Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M110.185744
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Funding
- Natural Sciences and Engineering Research Council of Canada
- Alberta Ingenuity Centre for Carbohydrate Science
- Canada Foundation for Innovation
- University of Alberta
- Alberta Ingenuity Fund
- Alberta Heritage Foundation for Medical Research
- Medical Research Council [G0501478]
- MRC [G0501478] Funding Source: UKRI
- Medical Research Council [G0501478] Funding Source: researchfish
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In contrast to the well established multiple cellular roles of membrane vesicles in eukaryotic cell biology, outer membrane vesicles (OMV) produced via blebbing of prokaryotic membranes have frequently been regarded as cell debris or microscopy artifacts. Increasingly, however, bacterial membrane vesicles are thought to play a role in microbial virulence, although it remains to be determined whether OMV result from a directed process or from passive disintegration of the outer membrane. Here we establish that the human oral pathogen Porphyromonas gingivalis has a mechanism to selectively sort proteins into OMV, resulting in the preferential packaging of virulence factors into OMV and the exclusion of abundant outer membrane proteins from the protein cargo. Furthermore, we show a critical role for lipopolysaccharide in directing this sorting mechanism. The existence of a process to package specific virulence factors into OMV may significantly alter our current understanding of host-pathogen interactions.
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