Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 285, Issue 25, Pages 18973-18978Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R109.062612
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Funding
- National Institutes of Health [RGM084070A]
- Italian Funding of Basic Research (FIRB)
- Human Frontier Science Program
- Emory University Research Council
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Single-molecule experimentation has contributed significantly to our understanding of the mechanics of nucleoprotein complexes that regulate epigenetic switches. In this minireview, we will discuss the application of the tethered-particle motion technique, magnetic tweezers, and atomic force microscopy to (i) directly visualize and thermodynamically characterize DNA loops induced by the lac, gal, and lambda repressors and (ii) understand the mechanistic role of DNA-supercoiling and DNA-bending cofactors in both prokaryotic and eukaryotic systems.
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