Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 285, Issue 44, Pages 34240-34249Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M110.159152
Keywords
-
Categories
Funding
- National Institutes of Health [AI50050, HL094463, HL62244, HL096972, GM38060]
- American Heart Association, MidAtlantic Affiliate [0855424E]
Ask authors/readers for more resources
Heparan sulfate is a sulfated glycan that exhibits essential physiological functions. Interrogation of the specificity of heparan sulfate-mediated activities demands a library of structurally defined oligosaccharides. Chemical synthesis of large heparan sulfate oligosaccharides remains challenging. We report the synthesis of oligosaccharides with different sulfation patterns and sizes from a disaccharide building block using glycosyl-transferases, heparan sulfate C-5-epimerase, and sulfotransferases. This method offers a generic approach to prepare heparan sulfate oligosaccharides possessing predictable structures.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available