Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 285, Issue 51, Pages 39575-39579Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R110.180109
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Funding
- Swedish Cancer Fund
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Estrogens act by binding to and activating two estrogen receptors (ERs), ER alpha and ER beta. Transcriptional regulation by ERs is controlled by a complex array of factors such as ER-ligand binding, the DNA sequence bound by ERs, ER-interacting cofactors, and chromatin context. This minireview will provide an overview of the most recent advances in the identification of ER beta-regulated target gene networks and ER beta DNA-binding sites. We also highlight the recent work establishing new roles of ER beta signaling, including protective functions in the epithelial-mesenchymal transition and in atherosclerosis, as well as regulation of cell proliferation in the colon.
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