Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 284, Issue 30, Pages 19781-19785Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R109.013219
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Funding
- American Heart Association
- Ohio Eminent Scholar Program
- Wellcome Trust
- British Heart Foundation
- Medical Research Council
- MRC [G0500707] Funding Source: UKRI
- British Heart Foundation [RG/09/003/27122] Funding Source: researchfish
- Medical Research Council [G0500707] Funding Source: researchfish
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Collagen peptides have been used to identify binding sites for several important collagen receptors, including integrin alpha(2)beta(1), glycoprotein VI, and von Willebrand factor. In parallel, the structures of these collagen receptors have been reported, and their interactions with collagen peptides have been studied. Recently, the three-dimensional structure of the intact type I collagen fiber from rat tail tendon has been resolved by fiber diffraction. It is now possible to map the binding sites of platelet collagen receptors onto the intact collagen fiber in three dimensions. This minireview will discuss these recent findings and their implications for platelet activation by collagen.
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