Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 284, Issue 28, Pages 18692-18698Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M109.012732
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Funding
- National Institutes of Health [GM68418]
- NCI
- Cancer Center [CA21765]
- American Lebanese Syrian Association Charities
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The kinetochore, which consists of centromere DNA and structural proteins, is essential for proper chromosome segregation in eukaryotes. In budding yeast, Sgt1 and Hsp90 are required for the binding of Skp1 to Ctf13 ( a component of the core kinetochore complex CBF3) and therefore for the assembly of CBF3. We have previously shown that Sgt1 dimerization is important for this kinetochore assembly mechanism. In this study, we report that protein kinase CK2 phosphorylates Ser(361) on Sgt1, and this phosphorylation inhibits Sgt1 dimerization.
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