Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 284, Issue 36, Pages 23912-23924Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M109.036483
Keywords
-
Categories
Funding
- French network Herpesviruses and Cancer, Association pour la Recherche sur le Cancer Grant [3572]
- Groupement des Entreprises Francaises dans la Lutte contre le Cancer (GEFLUC)
- Tunisian Ministry of Higher Education, Research and Technology
- INSERM
- Institut Francilien de Recherche en Nephrologie et Transplantation
- Association Nouvelles Recherches Biomedicales
- Association pour l'Utilisation du Rein Artificiel
- Naturalia and Biologia
Ask authors/readers for more resources
Epstein-Barr virus, a ubiquitous human herpesvirus, is associated with the development of carcinomas and lymphomas. We previously showed that transforming growth factor beta 1 (TGF-beta 1) mediated the virus to enter the lytic cycle, which is triggered by expression of Z Epstein-Barr virus replication activator (ZEBRA), through the ERK 1/2 MAPK signaling pathway. We report here that Akt, activated downstream from ERK 1/2, was required for TGF-beta 1-induced ZEBRA expression and enabled Smad3, a mediator of TGF-beta 1 signaling, to be acetylated by direct interaction with the co-activator CREB-binding protein and then to regulate TGF-beta 1-induced ZEBRA expression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
