Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 284, Issue 13, Pages 8217-8221Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R800032200
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Funding
- Fonds voor Wetenschappelijk Onderzoek
- Centrum voor Gezwelziekten
- Geconcerteerde Onderzoeksacties of Ghent University
- [IAP6/18]
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Inappropriate functioning of the immune system is linked to immune deficiency, autoimmune disease, and cancer. It is therefore not surprising that intracellular immune signaling pathways are tightly controlled. One of the best studied transcription factors in immune signaling is NF-kappa B, which is activated by multiple receptors and regulates the expression of a wide variety of proteins that control innate and adaptive immunity. A20 is an early NF-kappa B-responsive gene that encodes a ubiquitin-editing protein that is involved in the negative feedback regulation of NF-kappa B signaling. Here, we discuss the mechanism of action of A20 and its role in the regulation of inflammation and immunity.
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