Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 284, Issue 18, Pages 11755-11759Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R800071200
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Funding
- National Institutes of Health [UO1 CA84128-06, P50 CA092131]
- NCI [RO1 CA107166]
- Prostate Cancer Foundation [DOD PC031130]
- Damon Runyon Cancer Foundation
- NATIONAL CANCER INSTITUTE [P50CA092131, U01CA084128, R01CA107166] Funding Source: NIH RePORTER
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Like normal stem cells, cancer stem cells have the capacity for indefinite proliferation and generation of new cancerous tissues through self-renewal and differentiation. Among the major intracellular signaling pathways, WNT, SHH, and NOTCH are known to be important in regulating normal stem cell activities, and their alterations are associated with tumorigenesis. It has become clear recently that PTEN (phosphatase and tensin homologue) is also critical for stem cell maintenance and that PTEN loss can cause the development of cancer stem cells and ultimately tumorigenesis.
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