Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 59, Issue 11, Pages 7104-7108Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01117-15
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Funding
- National Institutes of Health/Fogarty training grant [D43 TW008270]
- National Institutes of Health [R01AI093358, K23AI099019]
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MIC testing for Mycobacterium tuberculosis is now commercially available. Drug susceptibility testing by the MycoTB MIC plate has not been directly compared to that by the Bactec MGIT 960. We describe a case of extensively drug-resistant tuberculosis (XDR-TB) in Tanzania where initial MIC testing may have prevented acquired resistance. From testing on archived isolates, the accuracy with the MycoTB plate was >90% for important first-and second-line drugs compared to that with the MGIT 960, and clinically useful quantitative interpretation was also provided.
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