Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 22, Issue 4, Pages 345-U99Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2996
Keywords
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Funding
- Damon Runyon Cancer Research Foundation [07-13]
- Pew Scholars program
- Searle Scholars program
- US National Institutes of Health (NIH) [DP2 EB020402-01]
- NIH [GM44589]
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Cytoplasmic dynein associates with dynactin to drive cargo movement on microtubules, but the structure of the dynein-dynactin complex is unknown. Using electron microscopy, we determined the organization of native bovine dynein, dynactin and the dynein-dynactin-microtubule quaternary complex. In the microtubule-bound complex, the dynein motor domains are positioned for processive unidirectional movement, and the cargo-binding domains of both dynein and dynactin are accessible.
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