Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 23, Issue 1, Pages 24-30Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.3145
Keywords
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Funding
- Long-Term Human Frontiers Fellowship [LT000149/2010-1]
- Medical Research Council (MRC) [G1001690]
- Isaac Newton Trust [RG76588]
- Biotechnology and Biological Sciences Research Council [BB/M022994/1]
- Gurdon Institute
- Wellcome Trust [092096/Z/10/Z, 101050/Z/13/Z]
- Cancer Research UK [C6946/A14492]
- MRC Cancer Unit core grant
- BBSRC [BB/M022994/1] Funding Source: UKRI
- MRC [MR/P000479/1, MR/K011022/1, G1001690, MC_UU_12022/6] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/B/14647] Funding Source: researchfish
- Medical Research Council [MR/K011022/1, MR/P000479/1, MC_UU_12022/6, G1001690] Funding Source: researchfish
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Methylation of cytosine deoxynucleotides generates 5-methylcytosine (m(5)dC), a well-established epigenetic mark. However, in higher eukaryotes much less is known about modifications affecting other deoxynucleotides. Here, we report the detection of N-6-methyldeoxyadenosine (m(6)dA) in vertebrate DNA, specifically in Xenopus laevis but also in other species including mouse and human. Our methylome analysis reveals that m(6)dA is widely distributed across the eukaryotic genome and is present in different cell types but is commonly depleted from gene exons. Thus, direct DNA modifications might be more widespread than previously thought.
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