Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 22, Issue 11, Pages 875-880Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.3106
Keywords
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Funding
- Cancer Institute New South Wales (NSW) Career Development Fellowship
- Cancer Council NSW [1069550, PG11-08]
- National Health and Medical Research Council of Australia [1009231, 1034564, 1088646]
- National Health and Medical Research Council of Australia [1088646] Funding Source: NHMRC
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Alternative lengthening of telomeres (ALT) involves homology-directed telomere synthesis. This multistep process is facilitated by loss of the ATRX or DAXX chromatin-remodeling factors and by abnormalities of the telomere nucleoprotein architecture, including altered DNA sequence and decreased TRF2 saturation. Induction of telomere-specific DNA damage triggers homology-directed searches, and NuRD-ZNF827 protein-protein interactions provide a platform for the telomeric recruitment of homologous recombination (HR) proteins. Telomere lengthening proceeds by strand exchange and template-driven DNA synthesis, which culminates in dissolution of HR intermediates.
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