Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 283, Issue 52, Pages 36494-36503Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M805333200
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Funding
- Italian Space Agency Molecules-to-Man (MoMa)
- Agenzia Spaziale Italiana - Istituto Nazionale di Astrofisica (ASI-INAF) [I/015/07/0]
- National Science Foundation Chemical Bond Center (CBC)
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We describe the nonenzymatic ligation of RNA oligomers in water. Dimers and tetramers are formed in a time-, pH-, and temperature-dependent reaction. Ligation efficiency depends on oligonucleotide length and sequence and is strongly enhanced by adenine-based nucleotide cofactors. Ligation of short RNA fragments could have liberated the prebiotic polymerization systems from the thermodynamically demanding task of reaching a (pre) genetically meaningful size by stepwise addition of one precursor monomer at the time.
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