Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 22, Issue 11, Pages 920-923Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.3111
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Funding
- Fonds de Recherche du Quebec Sante (FRQ-S)
- European Molecular Biology Organization long-term fellowship [ALTF 51-2014]
- Robertson Foundation
- Alfred P. Sloan Foundation
- Irma T. Hirschl Trust
- Human Frontier Science Program
- Leona M. and Harry B. Helmsley Charitable Trust for mass spectrometer instrumentation
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Eukaryotic ribosome biogenesis involves a plethora of ribosome-assembly factors, and their temporal order of association with preribosomal RNA is largely unknown. By using Saccharomyces cerevisiae as a model organism, we developed a system that recapitulates and arrests ribosome assembly at early stages, thus providing in vivo snapshots of nascent preribosomal particles. Here we report the stage-specific order in which 70 ribosome-assembly factors associate with preribosomal RNA domains, thereby forming the 6-MDa small-subunit processome.
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