Journal
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
Volume 42, Issue 6, Pages 443-448Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10863-010-9314-7
Keywords
Epilepsy; Mitochondrial DNA mutations; POLG; Mitochondria
Categories
Funding
- Deutsche Forschungsgemeinschaft [TR3-A11, TR3-D12]
- BMBF [mitoNET 01GM0868]
- Stiftung fur Medizinische Wissenschaft (Frankfurt am Main)
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A broad variety of mutations of the mitochondrial DNA or nuclear genes that lead to the impairment of mitochondrial respiratory chain or mitochondrial ATP synthesis have been associated with epileptic phenotypes. Additionally, evidence for an impaired mitochondrial function in seizure focus of patients with temporal lobe epilepsy and Ammon's horn sclerosis, as well as, animal models of temporal lobe epilepsy has been accumulated. This implies a direct pathogenic role of mitochondrial dysfunction in the process of epileptogenesis and seizure generation in certain forms of epilepsy.
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