Journal
JOURNAL OF BIOCHEMISTRY
Volume 165, Issue 2, Pages 101-107Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvy068
Keywords
apoptosis; communication zone; MAM; mitochondria; response zone
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Funding
- MEXT of Japan [17H01533, 17H06414, 16K15230, 17H05691]
- Project for Cancer Research and Therapeutic Evolution (P-CREATE) from the Japan Agency for Medical Research and development, AMED [JP18cm0106109]
- Project for Psychiatric and Neurological Disorders from the Japan Agency for Medical Research and development, AMED [JP18dm0107136]
- Joint Usage/Research Program of Medical Research Institute, Tokyo Medical and Dental University
- Grants-in-Aid for Scientific Research [16K15230, 17H01533, 17H05691, 17H06414] Funding Source: KAKEN
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The recent development of scientific imaging techniques have lead to the identification of various novel organellar functions. Most of these functions are perfomred in limited areas within organelles. These local functional organelle regions are referred to as 'zones'. In mitochondria, there are various types of zones exist, including the apoptosis zone, necrosis zone, mitophagy zone, mitochondrial-derived vesicle budding zone, innate immunity zone, etc. The membrane contact site between mitochondria and the endoplasmic reticulum, which is referred to as MAM, is also considered a zone. This contact site is crucial for various biological events, such as lipid transfer, sterol exchange, Ca2+ transfer, autophagy and the suppression of neurological disorders. Therefore, the elucidation of organelle zones is essential towards a deeper understanding of cell biology.
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