Journal
JOURNAL OF BIOCHEMISTRY
Volume 154, Issue 3, Pages 219-228Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvt066
Keywords
aminopeptidase; ankylosis spondylitis; antigen presentation; autoimmune diseases; endoplasmic reticulum
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Funding
- Japan Society for the Promotion of Science
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Grants-in-Aid for Scientific Research [25293083, 23310160, 24659153, 24659099] Funding Source: KAKEN
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The human endoplasmic reticulum aminopeptidase (ERAP) 1 and 2 proteins were initially identified as homologues of human placental leucine aminopeptidase/insulin-regulated aminopeptidase. They are categorized as a unique class of proteases based on their subcellular localization on the luminal side of the endoplasmic reticulum. ERAPs play an important role in the N-terminal processing of the antigenic precursors that are presented on the major histocompatibility complex (MHC) class I molecules. ERAPs are also implicated in the regulation of a wide variety of physiological phenomena and pathogenic conditions. In this review, the current knowledge on ERAPs is summarized.
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