Journal
JOURNAL OF BIOCHEMISTRY
Volume 153, Issue 5, Pages 403-414Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvt022
Keywords
bacteria; GTPase; ribosome; ribosome maturation
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Funding
- Japan Society for the Promotion of Science [23380054]
- Grant for Hirosaki University Institutional Research
- Grants-in-Aid for Scientific Research [23380054, 23380045, 24658066, 24657114] Funding Source: KAKEN
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The ribosome is an RNA- and protein-based macromolecule having multiple functional domains to facilitate protein synthesis, and it is synthesized through multiple steps including transcription, stepwise cleavages of the primary transcript, modifications of ribosomal proteins and RNAs and assemblies of ribosomal proteins with rRNAs. This process requires dozens of trans-acting factors including GTP- and ATP-binding proteins to overcome several energy-consuming steps. Despite accumulation of genetic, biochemical and structural data, the entire process of bacterial ribosome synthesis remains elusive. Here, we review GTPases involved in bacterial ribosome maturation.
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