Journal
JOURNAL OF BIOCHEMISTRY
Volume 150, Issue 3, Pages 257-266Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvr090
Keywords
biomarker; disease; disorder; metabolism; odour; olfactory; volatile organic compound
Categories
Funding
- MEXT, Japan
Ask authors/readers for more resources
Hundreds of volatile organic compounds (VOCs) are emitted from the human body, and the components of VOCs usually reflect the metabolic condition of an individual. Therefore, contracting an infectious or metabolic disease often results in a change in body odour. Recent progresses in analytical techniques allow rapid analyses of VOCs derived from breath, blood, skin and urine. Disease-specific VOCs can be used as diagnostic olfactory biomarkers of infectious diseases, metabolic diseases, genetic disorders and other kinds of diseases. Elucidation of pathophysiological mechanisms underlying production of disease-specific VOCs may provide novel insights into therapeutic approaches for treatments for various diseases. This review summarizes the current knowledge on chemical and clinical aspects of body-derived VOCs, and provides a brief outlook at the future of olfactory diagnosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available