Journal
JOURNAL OF BIOCHEMISTRY
Volume 149, Issue 4, Pages 357-359Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvr018
Keywords
endothelium; hydrogen sulfide; 3-mercaptopyruvate sulphurtransferase; smooth muscle; vasorelaxation
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Hydrogen sulfide (H2S) has been established as the third gaseous signaling molecule following nitric oxide and carbon monoxide and participates in a variety of cellular functions such as modulation of neuronal transmission, endothelium-dependent vasorelaxation, stimulation of angiogenesis and regulation of insulin release. Although cystathionine beta-synthase and cystathionine gamma-lyase have been regarded as the main producers of H2S in many tissues including brain, liver and kidney, Kimura and his colleagues have recently communicated that 3-mercaptopyruvate sulphurtransferase coupled with cysteine (aspartate) aminotransferase is responsible for the production of H2S in the vascular endothelium of the thoracic aorta [Shibuya et al. (2009) J. Biochem. 146, 623-626]. This finding provides a new insight into the production of the physiologically important signaling molecule.
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