Journal
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
Volume 28, Issue 5, Pages 191-197Publisher
WILEY-BLACKWELL
DOI: 10.1002/jbt.21552
Keywords
Complex Traits; Host Susceptibility; Iron; Neurodegeneration; Paraquat; Parkinson's Disease; Toxicogenetics
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Funding
- National Institutes of Health [R01 ES019672, R01 NS060722, U01 NS082151, U01 AA016662, U01 AA013499]
- UTHSC Center for Integrative and Translational Genomics
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Paraquat is an herbicide used extensively in agriculture and has also been proposed to be a risk factor for Parkinson's disease. To date, experimental, clinical, and epidemiological data on paraquat neurotoxicity have been equivocal. In this short review, we discuss some technical and biological mechanisms that contribute to inconsistencies regarding paraquat neurotoxicity. We hypothesize that individual genetic variations in susceptibility generate major differences in neurotoxic risk and functional outcome. Identifying these heritable sources of variation in host susceptibility, and their role in complex gene-environment interactions, is crucial to identify risk biomarkers and to devise better prevention and treatment for those exposed to paraquat and other potential neurotoxicants.
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