Journal
NATURE REVIEWS RHEUMATOLOGY
Volume 11, Issue 7, Pages 401-414Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrrheum.2015.41
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Funding
- Japan Society for the Promotion of Science [26713036]
- Naito Memorial Foundation
- Uehara Memorial Foundation
- Japan Intractable Diseases Research Foundation
- Japan Rheumatic Disease Foundation
- Yokohama Foundation for Advancement of Medical Science
- Grants-in-Aid for Scientific Research [26713036] Funding Source: KAKEN
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Rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis and some other rheumatic diseases are genetically complex, with evidence of familial clustering, but not of Mendelian inheritance. These diseases are thought to result from contributions and interactions of multiple genetic and nongenetic risk factors, which have small effects individually. Genome-wide association studies (GWAS) of large collections of data from cases and controls have revealed many genetic factors that contribute to nonMendelian rheumatic diseases, thus providing insights into associated molecular mechanisms. This Review summarizes methods for the identification of gene variants that influence genetically complex diseases and focuses on what we have learned about the rheumatic diseases for which GWAS have been reported. Our review of the disease-associated loci identified to date reveals greater sharing of risk loci among the groups of seropositive (diseases in which specific autoantibodies are often present) or seronegative diseases than between these two groups. The nature of the shared and discordant loci suggests important similarities and differences among these diseases.
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