Journal
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
Volume 28, Issue 3, Pages 233-246Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0883911513477750
Keywords
Poly(l-lactide-co-caprolactone) vascular graft without cells; endothelial cell lining; neovascularization; elastomer; cardiovascular bypass
Funding
- Korea Healthcare technology R&D Project, Ministry of Health & Welfare (MOHW), Republic of Korea [A110962]
Ask authors/readers for more resources
Synthetic vessel grafts have been used as vascular substitutes for cardiovascular bypass procedures. In this study, we developed a novel tubular double-layered poly(l-lactide-co-E-caprolactone) scaffold that did not require pretreatment with cell seeding by promoting autologous tissue regeneration by inducing the proliferation and differentiation of endothelial and smooth muscle progenitor cells after implantation. The patency and mechanical properties were maintained for one year after implantation, although 95% of the poly(l-lactide-co-E-caprolactone) scaffolds had degraded. After this period, there was a lining of endothelial cells, an accumulation of collagen and elastin, and the development of neovascularization inside the poly(l-lactide-co-E-caprolactone).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available