Journal
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
Volume 26, Issue 5, Pages 508-518Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0883911511415390
Keywords
bacterial cellulose; hydrogel; extracellular matrix; growth factor; wound healing; biodegradability; biocompatibility
Funding
- National Science Council, Taiwan [NSC 96-2622-E-034-008-CC3]
- TCI Company Ltd
- Department of Health, Taiwan [DOH100-TD-B-111-003, DOH100-TD-N-111-004]
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To improve the biocompatibility of bacterial cellulose hydrogel (BCHG), different extracellular matrices (ECMs; collagen, elastin, and hyaluronan) and growth factors (B-FGF, H-EGF, and KGF) were immobilized onto macroporous BCHG. The microstructure of BCHG had inter-connective channels that were well-integrated with the alginate gel. The alginate gel formed a semi-penetrate hydrogel that allowed the ECM and growth factor to diffuse under physiological conditions. The H-EGF and collagen-modified BCHG supported the growth of human skin fibroblast. The improved BCHG was biocompatible and exhibited desirable skin substitute characteristics that could be used as a deliver vehicle for therapeutic compounds during wound healing.
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