Journal
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
Volume 25, Issue 5, Pages 483-497Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0883911510375175
Keywords
superporous hydrogel; physical crosslinking; 2-hydroxyethyl methacrylate; ionotropic gelation; toxicity
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Superporous hydrogels (SPHs), based on poly(2-hydroxyethyl methacrylate) (PHEMA), were prepared by adding minute amounts of an ioncomplexable hydrophilic acrylic acid. PHEMA SPHs are generally strong, but their swelling is minimal. To improve the swelling, different poly(HEMA-co-acrylic acid) hydrogels were polymerized and crosslinked, then physically treated with divalent calcium and trivalent aluminum cations. The incorporation of acrylic acid copolymer into the SPH, followed by crosslinking of the copolymer with calcium or aluminum ions produced SPHs with improved swelling and strength. Cells in the presence of hydrogel showed high viability indicating the absence of cytotoxicity and stimulatory effect.
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