Journal
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
Volume 25, Issue 2, Pages 169-184Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0883911509357863
Keywords
biomaterials; natural-based polymers; smart hydrogels; drug release; hydrogels; PNIPAAm; hyaluronic acid conjugates; semi-IPN hydrogels; temperature sensitive hydrogels; pH-sensitive hydrogels
Funding
- Fundacao para a Ciencia e Tecnologia (Portugal) [PTDC/FIS/68517/2006, PTDC/QUI/68804/2006]
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New pH and temperature sensitive semi-interpenetrated polymer networks (semi-IPNs) were developed by combining cross-linked PNIPAAm with hyaluronic acid (HA). At pH 7.4, the PNIPAAm/HA semi-IPN hydrogels had significantly greater and faster swelling at 25 degrees C and a more complete deswelling at 37 degrees C than PNIPAAm hydrogels. The temperature-dependent reversibility behavior was analyzed for biomaterial applications. Gentamicin was incorporated as a model drug, and the release profile from the hydrogels was followed under physiological conditions. The presence of HA, even in small quantities, allowed a more complete release of the gentamicin from the hydrogel. The PNIPAAm/HA semi-IPN hydrogels respond to both changes in temperature and pH making it suitable as a delivery system for therapeutics.
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